Ergotamine derivatives: As a result of the theoretic odds of ergotism, the brand new concurrent use of azithromycin that have ergot derivatives isn’t required (pick section 4.4).
Regardless of if neutropenia could have been regarding the the means to access rifabutin, good causal relationship to combination which have azithromycin was not built (pick Part 4
Alerting is preferred about co-administration of them medications with Azithromycin because of the known improving effectation of these types of medications when put concurrently on the macrolid antibiotic drug erythromycin.
Co-government of atorvastatin (ten milligrams every single day) and you may azithromycin (five hundred mg everyday) don’t replace the plasma concentrations away from atorvastatin (according to an effective HMG CoA-reductase suppression assay). Yet not, post-sale cases of rhabdomyolysis from inside the patients getting azithromycin which have statins possess started stated.
For the a good pharmacokinetic interaction research into the fit volunteers, no extreme perception is seen for the plasma levels of carbamazepine or the effective metabolite in the customers getting concomitant azithromycin.
Even though a great causal matchmaking has not been created, believe is made available to the fresh regularity of monitoring prothrombin time whenever azithromycin is used within the people searching coumarin-type oral anticoagulants
Cisapride was metabolized about the liver because of the chemical CYP 3A4. Just like the macrolides inhibit that it enzyme, concomitant government from cisapride might cause the increase away from QT interval prolongation, ventricular arrhythmias and you will torsades de pointes.
In the a pharmacokinetic research exploring the results of a single dose away from cimetidine, considering couple of hours prior to azithromycin, to the pharmacokinetics out of azithromycin, zero modification regarding azithromycin pharmacokinetics was viewed.
Inside the good pharmacokinetic interaction investigation, azithromycin didn’t alter the anticoagulant effectation of one 15 milligrams dosage off warfarin administered to help you match volunteers. There have been records gotten in the post-business age of potentiated anticoagulation subsequent to co-government off azithromycin and coumarin-type of dental anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-administration out of a 600 mg solitary dose regarding azithromycin and you will 400 mg efavirenz each day to have one week did not end in one medically tall pharmacokinetic connections.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-management of just one dosage off 1200 milligrams azithromycin didn’t come with statistically high effect on the latest pharmacokinetics off indinavir administered since 800 milligrams three times daily for five days.
Inside the suit volunteers, co-management out-of azithromycin five-hundred mg/big date having 3 days did not produce clinically extreme changes in the fresh new pharmacokinetics and you may pharmacodynamics of just one 15 milligrams dosage out-of midazolam.
Co-management regarding azithromycin (1200 milligrams) and you may nelfinavir within steady state (750 mg three times everyday) contributed to improved azithromycin concentrations. No medically high negative effects have been observed without serving improvement will become necessary.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have said zero proof a conversation between azithromycin and terfenadine. There have been infrequent cases stated where in fact the possibility of particularly a relationships could not end up being entirely excluded; however there can be zero particular facts you to definitely particularly a relationship had occurred.
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