The partnership between BMD and you will pounds are stronger than anywhere between Body mass index and you can BMD

step 3.step 3. Exposure Situations

Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).

Both Body mass index and you may lbs was in fact synchronised which have BMD, and you can BMC signs additionally the most effective Pearson’s relationship coefficients was basically discovered anywhere between pounds and you may BMC altogether cool and you will trochanter nations and brand new weakest ones was basically ranging from Bmi and you may femoral shoulder BMC. The latest correlations anywhere between many years and you will BMD and you can BMC indications was basically bad (Dining table 4).

Age-adjusted ratio regarding BMD and BMC version said by the Bmi and you can pounds try revealed inside Desk 5. Weight had a tendency to tell you deeper differences in BMD and BMC delivery after all the brand new examined skeletal web sites compared to Bmi. It was mirrored from the steeper mountain (?) of your own particular linear regression lines. The most effective difference in BMD and you can BMC delivery appeared on trochanter BMC followed closely by lumbar BMC getting weight. Lbs is a vital predictor off BMD and BMC variation into the earlier Iranian people.

cuatro. Talk

In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11] https://assets.capitalfm.com/2011/36/gq-men-of-the-year-awards-2011-10-1315386939-view-1.jpg” alt=”sugar baby in Nevada”>. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.

The systems by which fat exerts positive effects into the BMD standing aren’t totally obvious. This new putative system benefit off fatty tissue for skeletal stability most likely stays in the fresh new role many adipokines inside the bones restorations using affect each other development and resorption. Has just, limbs might have been considered a keen hormonal organ impacting weight control and you may sugar homoeostasis through the procedures out-of bone-derived issues eg osteocalcin and osteopontin [23, 34–36]. The fresh new putative crosstalk between weight additionally the bones comprises a beneficial homoeostatic opinions system in which adipokines and you may particles released of the osteoblasts and you may osteoclasts represent the web link regarding a working bone-adipose axis [34–36]. Being obese is even of this BMD by transformation off androgen in order to the hormone estrogen , hence improves limbs bulk in visitors [38, 39] and you can keeps fit plasma levels of insulin and you may regulating items and additionally insulin-such as for example progress foundation-step 1, leptin, and you can adiponectin . In addition, obesity provides padding with the hip in case there is a slide . But not, the newest systems where a few of these occurrences exist will always be uncertain.